Table 2.

Univariate analysis for predictors for longer leflunomide drug survival

Univariate analysis		Multivariate analysis
Factor	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)
Concomitant systemic corticosteroids	0.05		0.006
No		1 (reference)		1 (reference)
Yes		1.35 (1.00, 1.83)		1.58 (1.14, 2.21)
ESR start (mm h–1)	0.04		0.03
≥ 35		1 (reference)		1 (reference)
<35		1.38 (1.01, 1.88)		1.42 (1.03, 1.96)
Rheumatologist	0.095	0.60–2.661	0.02	0.54–2.301

95% CI, 95% confidence interval; ESR start, erythrocyte sedimentation rate at the start of leflunomide therapy.

¹Maximal contrasts between rheumatologists.