Table 3.

Final population pharmacokinetic model of A77 1726 in RA patients

Parameter estimation	Value	Precision of estimate (% CV)
Structural model
CL/F (l h−1) = θ1 × (1 + θ3 × (AGE−60))
V/F (l) = θ2 × WT
θ1	0.0184(0.0146, 0.0222)†	10.7
θ2	0.155*
θ3	−0.0216(−0.0383, −0.0049)†	39.5
Variance model
Inter-individual variability in CL/F (%)	50.2	25.5
Residual random error (%)	8.5	21.3

WT: Weight.

^*Fixed in all modelling.

^†95% confidence interval.