Table 3.
Mean (%CV) steady-state pharmacokinetic parameters for ebastine and carebastine
| Parameter | Ebastine day 5 | Ebastine day 13 | Change day 13 vs. day 5 | Carebastine day 5 | Carebastine day 13 | Change day 13 vs. day 5 |
|---|---|---|---|---|---|---|
| AUC (ng h−1 ml−1) | 17.92 | 761.56* | ×42.5 | 5688.4 | 8192.2* | ×1.4 |
| (82.0) | (36.8) | (29.0) | (22.1) | |||
| Cmax (ng ml−1) | 3.75 | 58.95* | ×15.7 | 344.62 | 384.19* | ×1.1 |
| (73.2) | (37.2) | (33.0) | (21.8) | |||
| Cmin (ng ml−1) | 0.19 | 14.85* | ×78.2 | 145.3 | 333.8* | ×2.3 |
| (98.5) | (35.3) | (31.5) | (21.7) | |||
| Tmax (h) | 2.42 | 4.30* | ×1.8 | 4.8 | 16.4* | ×3.4 |
| (46.9) | (36.4) | (37.7) | (102.8) |
*
Statistically significantly different from day 5 (P < 0.05).