Table 1.
Pharmacokinetic parameters (mean, 95%CI) of DEAQ in 20 children with falciparum malaria who received oral amodiaquine (10 mg kg-1 day-1×3 days)
| Patient no. | Cmax (µg l–1) | Tmax (days) | AUC0-14 (µg l−1 day) | AUCtotal (µg l−1 day) | t1/2 (days) | MRT (days) |
|---|---|---|---|---|---|---|
| 01 | 735.1 | 3 | 2772.8 | 4361.4 | 3.5 | 6.8 |
| 02 | 351.8 | 3 | 2220.4 | 2407.1 | 3.3 | 6.6 |
| 03 | 399.7 | 3 | 1351.4 | 2827.7 | 6.7 | 10.5 |
| 04 | 407.8 | 3 | 3881.2 | 5863.7 | 8.4 | 13.0 |
| 05 | 226.0 | 3 | 1337.2 | 1445.9 | 3.4 | 6.1 |
| 06 | 590.5 | 3 | 4052.3 | 5825.2 | 7.7 | 11.9 |
| 07 | 282.4 | 1.5 | 224 8.9 | 3258.3 | 7.9 | 12.2 |
| 08 | 278.2 | 3 | 2198.4 | 3516.4 | 9.3 | 14.2 |
| 09 | 451.2 | 0.08 | 2988.5 | 10472.4 | 30.5 | 43.3 |
| 10 | 273.7 | 3 | 1416.6 | 3983.0 | 8.8 | 14.2 |
| 11 | 416.6 | 1 | 3154.5 | 3774.9 | 5.1 | 8.1 |
| 12 | 262.2 | 0.08 | 1752.5 | 5157.3 | 23.6 | 33.9 |
| 13 | 525.4 | 3 | 4505.3 | 5469.6 | 5.1 | 8.8 |
| 14 | 228.7 | 2 | 1158.6 | 4450.8 | 13.5 | 20.6 |
| 15 | 280.4 | 3 | 2438.1 | 8414.6 | 29.1 | 41.7 |
| 16 | 310.0 | 3 | 2673.6 | 3796.3 | 7.1 | 11.8 |
| 17 | 462.4 | 3 | 3949.6 | 5632.3 | 7.1 | 11.9 |
| 18 | 245.9 | 5 | 2125.0 | 2507.0 | 4.2 | 8.6 |
| 19 | 344.0 | 0.08 | 1835.1 | 2415.9 | 6.8 | 10.0 |
| 20 | 303.8 | 3 | 2674.8 | 4672.7 | 10.6 | 16.3 |
| Mean | 368.8 | 3.0* | 2536.7 | 4512.6 | 10.1 | 15.5 |
| 95% CI | 306.6–431.0 | 0.08–5.0* | 2078.2–2995.2 | 3517.3–5507.9 | 6.3–13.9 | 10.3–20.7 |
*
Median value with range.