Table 3.
Effect of prior carboplatin therapy on melphalan pharmacokinetic parameters
| Parameter (units) | No carboplatin | Carboplatin | Difference (95% CI)‡ | Significance |
|---|---|---|---|---|
| Children (n) | 27 | 25 | ||
| Age (years) Median (interquartile range) | 5.7 (3.3–11.4) | 5.0 (3.0–8.7) | −0.9, 3.6 | NS* |
| Prior TBI (no. children) Yes/No | 4/13 | 8/17 | NS† | |
| CL (l h−1) Median (interquartile range) | 13.1 (9.1–20.4) | 7.3 (5.7–9.8) | 4.3, 12.7 | P < 0.001* |
| CL (l h−1 m−2) Median (interquartile range) | 15.5 (12.4–19.9) | 10.2 (7.7–12.4) | 3.6, 8.4 | P < 0.001* |
| Vss (l) Median (interquartile range) | 11.9 (8.4–18.5) | 8.9 (6.8–10.3) | 2.4, 11.7 | P < 0.005* |
| Vss (l m−2) Median (interquartile range) | 4.9 (12.7–18.3) | 12.2 (8.5–13.4) | 2.0, 6.3 | P < 0.001* |
| Vz (l) Median (interquartile range) | 13.9 (9.7–19.8) | 11.6 (8.8–13.6) | 1.7, 12.3 | P < 0.05* |
| Vz (l m−2) Median (interquartile range) | 17.5 (14.6–20.5) | 15.4 (11.1–17.8) | 0.6, 5.9 | P < 0.05* |
| t1/2 (h) Median (interquartile range) | 0.76 (0.67–0.99) | 1.0 (0.81–1.25) | −0.36, −0.04 | P < 0.005* |
| MRT (h) Median (interquartile range) | 0.92 (0.81–1.18) | 1.12 (0.91–1.27) | −0.32, 0.07 | NS* |
*
Mann–Whitney test;
†
Chi square test, NS: Not significant;
‡
Lower and upper limits of the 95% confidence interval of the difference