Table 2.
Pharmacokinetic measures of free, and total mycophenolic acid in adult renal allograft recipients on day 5 after transplantation
| Total(n = 42) | Cyclosporin(n = 32) | Tacrolimus(n = 10) | P-value[95% CI] | |
|---|---|---|---|---|
| Total mycophenolic acid | ||||
| AUC0−6 (mg h−1 l−1) | 22.0 ± 9.2(3.7–49.1) | 20.8 ± 8.4(3.7–44.4) | 25.6 ± 11.1(10.7–49.1) | 0.16[− 11.4, 1.89] |
| C0 (mg l−1) | Median 0.9[0.6–1.6] | Median 0.8[0.6–1.3] | Median 1.6[1.4–3.0] | 0.002 |
| Free mycophenolic acid | ||||
| AUC0−6 (mg h−1 l−1) | 1.2 ± 0.8(0.2–2.0) | 1.2 ± 0.8(0.2–3.7) | 1.1 ± 0.6(0.5–2.0) | 0.82[− 0.5, 0.6] |
| C0 (µg l−1) | Median 43.1[18.9–75.0] | Median 37.1[12.9–73.8] | Median 61.5[43.8–76.0] | 0.10 |
| Free mycophenolic acid fraction* | ||||
| % free/total | Median 4.8[3.0–8.1] | Median 5.0[3.1–8.5] | Median 4.2[2.9–6.9] | 0.49 |
Data are mean ± SD and range of values, or median [IQR], depending on data type. 95% CI is the confidence interval on the difference between means. AUC0−6, area under the curve from 0 to 6 h; C0, trough concentration.
*
Value calculated from AUC0−6 results only.