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Table 3.

Pharmacokinetic measures of free, and total MPAG in adult renal transplant recipients on day 5 after transplantation

	Total (n = 42)	Cyclosporin (n = 32)	Tacrolimus (n = 10)	P-value
Total mycophenolic acid glucuronide
AUC₀₋₆ (mg h⁻¹ l⁻¹)	Median 714.3 [462.8–1001.9]	Median 714.3 [474.6–1048.3]	Median 694.1 [462.8–824.7]	0.54
C₀ (mg l⁻¹)	Median 87.3 [51.3–143.4]	Median 87.8 [54.5–164.8]	Median 70.2 [47.8–143.4]	0.59
Free mycophenolic acid glucuronide
AUC₀₋₆ (mg h⁻¹ l⁻¹)	Median 177.2 [121.5–328.2]	Median 177.2 [131.0–339.0]	Median 167.2 [109.0–214.5]	0.65
C₀ (mg l⁻¹)	Median 18.4 [11.4–43.0]	Median 18.4 [11.3–45.7]	Median 17.8 [11.5–26.3]	0.76
Free mycophenolic acid glucuronide fraction^*
% free/total	Median 27.4 [23.3–33.1]	Median 28.2 [23.2–32.9]	Median 26.9 [23.6–35.8]	0.63

Data are expressed as median [IQR]. AUC₀₋₆, Area under the curve from 0 to 6 h; C₀, trough concentration.

Value calculated from AUC₀₋₆ results only.