Table 2.
Final parameter estimates from the baseline and covariate model
| Baseline Model | Covariate Model | |||
|---|---|---|---|---|
| Parameter | Value | SE (CV%) | Value | SE (CV%) |
| CL (l h−1) | 0.536 | 15.3 | renal = 0.681/80 ml min−1 | 33.3 |
| non renal = 0.229 | 49.8 | |||
| Vc (l) | 3.45 | 17.8 | 5.22/80 kg (WT) | 18.8 |
| Ka (h−1) | 0.217 | 11.6 | 0.255 | 16.2 |
| Vp (l) | 32.8 | 23.8 | 29.6 | 22.6 |
| Q (l h−1) | 0.620 | 20.2 | 0.632 | 21.2 |
| Basal anti-Xa activity (IU l−1) | 45.8 | 32.3 | 49.9 | 30.1 |
| ωCL(%CV) | 43.1 | 50.3 | 32.7 | 62.3 |
| ωVc (%CV) | 61.8 | 32.5 | 34.4 | 72.2 |
| ωQ (%CV) | 68.3 | 37.0 | 69.8 | 41.9 |
| ωBasal (%CV) | 84.9 | 29.4 | 76.6 | 30.2 |
| Additive error σ1 (IU l−1) | 51.1 | 41.0 | 52.4 | 37.5 |
| Proportional error σ2 (%CV) | 19.4 | 36.2 | 20.0 | 35.6 |