Table 2.
Reproducibility of baseline measurements and forearm blood flow (FBF) responses
| Baseline measurement | Mean difference (95% CI) | Repeatability coefficient | WCV (%) (95% CI) | ICC |
|---|---|---|---|---|
| SBP (mmHg) | 2.3 (−4.8, 9.5) | 13.4 | 4 (1–8) | 0.57 (−0.45, 0.94) |
| DBP (mmHg) | 3.3 (−1.7, 8.4) | 9.5 | 4 (1–7) | 0.42 (−0.59, 0.92) |
| Heart rate (bpm) | −1.0 (−6.3, 4.3) | 10.0 | 6 (1–12) | 0.90 (0.31, 0.99) |
| FBFinfused (ml min−1 dl−1 forearm) | −0.4 (−1.5, 0.8) | 2.2 | 27 (5–49) | 0.70 (−0.26, 0.96) |
| FBFnon-infused (ml min−1 dl−1 forearm) | 0.2 (−0.6, 0.9) | 1.4 | 23 (4–41) | 0.36 (−0.64, 0.91) |
| FBF-ratio | −0.1 (−0.5, 0.3) | 0.7 | 20 (4–36) | 0.68 (−0.29, 0.96) |
| FBF response | Method of data expression | Mean difference (95% CI) | Repeatability coefficient | WCV (%) | ICC |
|---|---|---|---|---|---|
| FBF45 | FBFinfused | 0.3 (−1.9, 2.4) | 4.1 | 11 (2–19) | 0.82 (0.02, 0.95) |
| FBF-ratio | −0.7 (−4.1, 2.7) | 6.4 | 37 (7–66) | −0.22 (−0.88, 0.72) | |
| FBFinfused% | 29 (−154, 212) | 342 | 29 (5–52) | 0.56 (−0.46, 0.94) | |
| FBF-ratio% | −8 (−253, 237) | 458 | 40 (7–72) | 0.24 (−0.71, 0.88) | |
| AUC0−45 | FBFinfused | 15 (−81, 110) | 178 | 12 (2–22) | 0.78 (−0.07, 0.98) |
| FBF-ratio | 4 (−83, 90) | 162 | 26 (5–46) | 0.18 (−0.74, 0.87) | |
| FBFinfused% | 1613 (−3932, 7158) | 10 359 | 25 (5–45) | 0.56 (−0.46, 0.94) | |
| FBF-ratio% | 2144 (−3908, 8197) | 11 307 | 26 (5–47) | 0.24 (−0.71, 0.88) | |
| ΔFBF0−45 | FBFinfused | 0.6 (−1.7, 3.0) | 4.4 | 14 (3–25) | 0.75 (−0.15, 0.97) |
| FBF-ratio | −0.6 (−3.8, 2.6) | 6.0 | 43 (8–77) | −0.23 (−0.88, 0.71) | |
| FBFinfused% | 29 (−154, 212) | 342 | 29 (5–52) | 0.56 (−0.46, 0.94) | |
| FBF-ratio% | −8 (−253, 237) | 458 | 40 (7–72) | 0.24 (−0.71, 0.88) |
WCV, within-subject coefficient of variation; ICC, intraclass correlation coefficient; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBFinfused, forearm blood flow in the infused arm; FBFnon-infused, forearm blood flow in the noninfused arm; FBF-ratio, ratio of forearm blood flow between the infused and noninfused arm. FBF45, FBF at 45 min; AUC0−45, the area under the curve from baseline to 45 min; ΔFBF0−45, change in FBF from baseline to 45 min. FBF response is expressed as: (1) FBFinfused (ml min−1 dl−1 forearm) (2) FBF-ratio (3) percentage change from baseline in FBF in the infused arm (FBFinfused%,%) and (4) percentage change from baseline in FBF-ratio (FBF-ratio%, %).