Figure 1.

Median plasma raloxifene concentrations after oral administration of 120 mg raloxifene hydrochloride to healthy subjects (open circles) or patients with renal impairment (closed circles). Two curves from the compartmental model (Method III) using mean values are shown (for healthy group: A₁ = 3.8 ng ml⁻¹, k_a1 = 0.36 h⁻¹, k_e1 = 0.29 h⁻¹, A₂ = 1.97 ng ml⁻¹, k_a2 = 0.059 h⁻¹, k_e2 = 0.036 h⁻¹; and for the renal group: A₁ = 1.84 ng ml⁻¹, k_a1 = 0.37 h⁻¹, k_e1 = 0.21 h⁻¹, A₂ = 3.1 ng ml⁻¹, k_a2 = 0.05 h⁻¹, k_e2 = 0.027 h⁻¹). LLQ = lower limit of quantification