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Summary of genotype–phenotype associations for genes in which variant alleles were observed
| Polymorphism | Pharmacokinetic parameters |
|---|---|
| ABCB1 C3435T (CC vs CT + TT) | CPT-11 Cmax (P = 0.047) |
| ABCB1 haplotypes | |
| ″″″″(CC-GG-CC vs. CT-GT-CT vs TT-TT-TT) | SN-38G: Cmax (P = 0.055) |
| ″″″″ABCC2 C-24T (CC vs CT vs TT) | CPT-11 AUC(0,∞) (P = 0.055) |
| ″″″″ABCG2–19572–19569 CTCA del (CTCA vs Het + CTCA del) | REC (AUCSN-38/AUCCPT-11) (P = 0.019) |
| ″″″″ABCG2 G34A (GG vs GA + AA) | CPT-11 Cmax (P = 0.056) |
