Table 3.

Effect of UGT1A1*28 on REG

Genotype	Reference	n	REG (mean ± SD) (median; range)
Wild-type	This study	17	33.4 ± 2.5 (25.6; 9.3–259.2)
	Mathijssen et al. [18]	32	7.6 ± 4.1 (6.6)
	Iyer et al. [35]	9	9.3 ± 11
Heterozygous	This study	10	36.8 ± 1.7 (34.3; 17.7–93.7)
	Mathijssen et al. [18]	19	7.1 ± 3.6 (6.6)
	Iyer et al. [35]	7	4.0 ± 1.7
Variant	This study	2	33.8 ± 1.3 (33.8; 27.7–41.2)
	Mathijssen et al. [18]	2	2.2 ± 5.2 (3.7)
	Iyer et al. [35]	4	2.4 ± 1.1