Table 2.
The effect of gemfibrozil on the pharmacodynamics of warfarin in 10 healthy subjects. A single oral dose of 10 mg racemic warfarin was ingested on day 3 of pretreatment with gemfibrozil 600 mg or placebo twice daily for 8 days
| Variable | Placebo phase | Gemfibrozil phase | Mean difference between placeboand gemfibrozil phase (95% CI) |
|---|---|---|---|
| PT baseline (s) | 21.6 ± 0.9 | 21.3 ± 0.6 | −0.34 (−0.94, 0.27) |
| AUE(0−168) (s · h) | 3941 ± 382 | 3884 ± 349 | −57.2 (−128, 13.8) |
| Emax (s) | 26.5 ± 5.3 | 26.6 ± 3.9 | 0.08 (−1.14, 1.31) |
Data are mean values (±SD).
PT, Thromboplastin time; AUE(0−168), area under the effect-time curve from 0 to 168 h; Emax, maximum value of PT.