Table 2.
Initial antibiotic regimens and patients’ outcomes
| Type of first treatment | N | Change to second-line therapy | Re-operation | Death | Clinical failure |
|---|---|---|---|---|---|
| Appropriate therapy1 | 147 (84.0%) | 2 (1.4%) | 14 (9.5%) | 7 (4.8%) | 20 (13.6%) |
| Amoxicillin +clavulanic, metronidazole | 2 | ||||
| Cefazolin, metronidazole | 5 | ||||
| Cefotaxime, clindamycine | 2 | ||||
| Cefotaxime, metronidazole | 43 | 2 | 8 | 3 | 10 |
| Cefuroxime, metronidazole | 95 | 6 | 4 | 10 | |
| Inappropriate therapy1 | 28 (16.0%) | 9 (32.1%) | 1 (3.4%) | 3 (10.7%) | 10 (35.7%) |
| Piperacillin | 1 | 1 | 1 | ||
| Piperacillin, gentamicin | 1 | 1 | 1 | ||
| Amoxicillin | 2 | 1 | 1 | ||
| Ceftazidime or cefotaxime or cefuroxime | 8 | ||||
| Flucoxacillin | 1 | 1 | 1 | 1 | |
| Gentamicin | 1 | ||||
| Metronidazole | 8 | 3 | 2 | 3 | |
| Norfloxacin or ofloxacin | 6 | 3 | 3 | ||
| Total | 175 | 11 (6.3%) | 15 (8.6%) | 10 (5.7%) | 30 (17.1%) |
1
Classification according to Surgical Infection Society Policy Statement [2]. Metronidazole, cefotaxime, cefuroxime, and the aminoglycosides were all administered as intravenous (i.v.) therapy.