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The pharmacokinetic model for nelfinavir and M8. D: the dose of nelfinavir per intake; F: the bioavailability of nelfinavir; ka: the first-order absorption rate constant for nelfinavir; km: the first-order metabolic rate constant; ke: the elimination rate constant for nelfinavir; V: the volume of distribution of nelfinavir; Vm: the volume of distribution of M8; kem: the elimination rate constant for M8
