Table 2.

Population pharmacokinetic parameters of nelfinavir and M8, 95% confidence interval and coefficient of variation of estimation error

Compound	Parameters	Estimate	V1 only 95% CI	CV%	Estimate	V1 and V2 95% CI	CV%
NFV	ka (h−1)	0.385	[0.178, 0.829]	41.1	0.397	[0.197, 0.800]	38.7
	CL/F (l h−1)	37.8	[31.8, 44.8]	2.4	37.3	[31.9, 43.6]	2.2
	V/F (l)	351	[198, 622]	5.0	309	[185, 516]	4.6
		0.322	–+	46.0	0.200	–+	67.4
	ωCL/F (%)	43.7	*	–*	34.3	–*	–*
		–***	–***	–***	27.8	–*	–*
	ωV/ F (%)	19.1	–*	–*	34.9	–*	–*
	aNFV (ng ml−1)	0**	–***	–***	375	–*	–*
M8	CLm/(Fkm) (l)	2060	[1113, 3815]	4.1	1670	[965, 2894]	3.8
	Vm/(Fkm) (l h−1)	901	[301, 2710]	8.3	866	[351, 2161]	6.9
		−0.715	–+	34.4	−0.590	–+	39.3
		0.0338	–+	33.0	0.0276	–+	38.4
		68.2	–*	–*	62.2	–*	–*
	aM8 (ng ml−1)	98.1	–*	–*	181	–*	–*
Both	σ (%)	40.9	–*	–*	35.3	–*	–*

⁺Not reported

^*Not estimated in nlme

^**Fixed to zero

^***Not applicable.