Table 1. Pharmacokinetic parameters for 13C-uracil in plasma.
Dose | Cmax (µg ml−1) | AUC12 h (µg h ml−1) | AUC∝ (µg h ml−1) | tmax (h) | λz (1 h−1) | t1/2 (h) | CL/F (l h−1) | Vd/F (l) |
---|---|---|---|---|---|---|---|---|
50 mg | 0.127 | 0.047 | 0.053 | 0.36 | 3.66 | 0.26 | 1082 | 466 |
±0.083 | ±0.022 | ±0.021 | ±0.10 | ±1.71 | ±0.22 | ±410 | ±500 | |
100 mg | 0.534 | 0.165 | 0.170 | 0.39 | 5.25 | 0.21 | 772 | 296 |
±0.430 | ±0.109 | ±0.107 | ±0.18 | ±2.92 | ±0.19 | ±368 | ±423 | |
200 mg | 1.205 | 0.545 | 0.567 | 0.54 | 2.91 | 0.32 | 464 | 296 |
±0.899 | ±0.325 | ±0.312 | ±0.25 | ±1.19 | ±0.26 | ±265 | ±480 |
Values: mean ± SD (n = 12).