Figure 2.

Mean ± SE mean plasma concentrations of nateglinide (A) and its M7 metabolite (B) in nine healthy subjects. A single oral dose of 30 mg nateglinide was given after 3 days' treatment with placebo or 600 mg gemfibrozil and 100 mg itraconazole (first dose 200 mg) twice daily. Insets depict the same data on a semilogarithmic scale. ○, during placebo; •, during gemfibrozil-itraconazole