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Individual apparent formation rate constants (kf) for the M7 metabolite of nateglinide. A single oral dose of 30 mg nateglinide was given to nine healthy subjects after 3 days' treatment with placebo or 600 mg gemfibrozil and 100 mg itraconazole (first dose 200 mg) twice daily (A) or to 10 healthy subjects after 4 days’ treatment with placebo or 200 mg fluconazole (first dose 400 mg) once daily (B] data from [18])
