Table 2.

Blood glucose response to nateglinide (given as a single 30-mg oral dose) in nine healthy subjects after 3 days’ treatment with placebo or 600 mg gemfibrozil and 100 mg itraconazole (first dose 200 mg) twice daily

Variable	Placebo phase	Gemfibrozil + itraconazole phase	Mean difference between phases (95% CI)	P
Mean change 0,3 h (mmol l−1)	−0.1 ± 0.7	−0.2 ± 0.7	−0.2 (− 0.6, 0.3)	0.4186
Mean change 0,7 h (mmol l−1)	−0.1 ± 0.5	−0.2 ± 0.5	−0.1 (− 0.5, 0.3)	0.5146
Mean change 0,12 h (mmol l−1)	−0.1 ± 0.6	−0.1 ± 0.4	−0.1 (− 0.4, 0.3)	0.7198
Maximum increase (mmol l−1)	1.3 ± 0.8	1.1 ± 0.7	−0.2 (− 0.8, 0.5)	0.5539
Maximum decrease (mmol l−1)	1.1 ± 0.7	1.2 ± 0.7	0.1 (− 0.5, 0.7)	0.7195

Values shown as mean ± SD unless otherwise indicated.