Table 2.

GPI 5693 summary pharmacokinetic parameters

Dose GPI5693	n	Cmax (ng ml−1)	SD	tmax (min)	SD	AUCinf (h ng−1 ml−1)	SD	t1/2 (h)	SD
100 mg	4	723	201	38	9	684	205	0.87	0.02
300 mg	9	2868	1384	42	10	2733	779	2.54	0.71
750 mg	8	9266	4650	51	53	8855	2498	4.78	2.21
1125 mg	4	15 742	3958	45	12	17 332	4542	6.05	0.70
750 mg fed	4	3057	1046	45	0	5144	1239	8.83	7.03
1125 mg fed	12	5309	2086	74	33	10 523	3292	6.88	6.71
1500 mg fed	12	6822	2229	93	37	15 218	3708	8.62	5.48