Table 1.
Effect of pregnancy on the nicotine N′-oxide metabolic ratios
| Urine nicotine N’-oxide/Urine nicotine | Urine nicotine N’-oxide/Plasma AUCnicotine (ml min−1) | |||
|---|---|---|---|---|
| Subject | Pregnant | Post-Partum | Pregnant | Post-Partum |
| 1 | 2.57 | 1.34 | 44.7 | 35.5 |
| 2 | 1.37 | 0.20 | 22.6 | 37.2 |
| 3 | –* | 36.5 | 27.8 | |
| 4 | 2.03 | 0.27 | 51.9 | 41.4 |
| 5 | 1.17 | 1.58 | 55.5 | 20.5 |
| 6 | 2.01 | 1.57 | 52.9 | 46.0 |
| 7 | 2.22 | 0.36 | 59.8 | 12.1 |
| 8 | 2.83 | 0.12 | 38.2 | 8.2 |
| Mean | 2.03 | 0.78 | 45.3 | 28.6 |
| SD | 0.60 | 0.68 | 12.3 | 13.8 |
Difference between pregnant and postpartum is statistically significant (P = 0.017, paired t-test for urine nicotine N′-oxide/urine nicotine ratio; P = 0.047, paired t-test for urine nicotine N′-oxide/plasma AUCnicotine ratio).
*
The ratio not calculated due to the concentration of urine nicotine below the limit of quantification.