Table 2.
The pharmacokinetic parameters of pitavastatin acid and pitavastatin lactone after a single dosing of 4 mg pitavastatin with water or grapefruit juice (mean and 95% confidence interval)
| Parameter | Water | GFJ | Difference between water and GFJ | P-value |
|---|---|---|---|---|
| Pitavastatin acid | ||||
| Cmax (ng mL−1) | 81.4 (22.2, 140.5) | 86.0 (42.7, 129.2) | 4.6 (−16.9, 26.0) | 0.48 |
| tmax (h) | 0.9 (0.4, 1.3) | 1.0 (0.6, 1.4) | 0.1 (−0.4, 0.6) | 0.58 |
| t1/2 (h) | 9.0 (7.7, 10.4) | 10.1 (7.6, 12.6) | 1.1 (−0.8, 2.9) | 0.12 |
| AUC0–24 (ng mL−1 h) | 194.2 (104.3, 284.0) | 220.1 (149.0, 291.3) | 26.0 (−5.0, 56.9) | <0.05 |
| Pitavastatin lactone | ||||
| Cmax (ng mL−1) | 49.5 (28.9, 70.1) | 64.4 (30.6, 98.2) | 14.9 (−3.3, 33.1) | 0.07 |
| tmax (h) | 1.6 (1.2, 2.1) | 1.6 (0.9, 2.2) | −0.1 (−0.9, 0.7) | 0.72 |
| t1/2 (h) | −6.1 (4.5, 7.7) | −9.8 (7.2, 12.3) | −3.5 (0.2, 6.8) | <0.05 |
| AUC0–24 (ng mL−1 h) | 269.3 (169.6, 369.1) | 351.0 (196.6, 505.5) | 81.7 (−4.2, 167.7) | <0.05 |
GFJ, Grapefruit juice; Cmax, maximum concentration in plasma; tmax, time to maximum plasma concentration; t1/2, elimination half-life; AUC0–24, area under the plasma concentration – time curve between time zero and 24 h after dosing.