Table 4.
Final estimates for population pharmacokinetic parameters of epinastine
| Final model equations | ||
| CL/F = (q1+ WT θ10) FOODCL/F FORMCL/F | ||
| V1/F = (θ2+ WT θ11) FOODV1/F | ||
| Q = θ3 | ||
| V2/F = θ4 | ||
| Ka = θ5 | ||
| ALAG = FOODALAG | ||
| FOODCL/F = θ6 if fed, 1 if fasted | ||
| FORMCL/F = θ9 if dry syrup, 1 if tablet | ||
| FOODV1/F = θ7 if fed, 1 if fasted | ||
| FOODALAG = θ8 if fed, 0 if fasted | ||
| Parameter | Estimate | SE |
|---|---|---|
|
| ||
| θ1 | 19.1 | 6.93 |
| θ2 | 174 | 68.4 |
| θ3 | 34.4 | 4.05 |
| θ4 | 452 | 106 |
| θ5 | 1.18 | 0.102 |
| θ6 | 1.41 | 0.0839 |
| θ7 | 1.75 | 0.169 |
| θ8 | 0.234 | 0.0354 |
| θ9 | 1.06 | 0.0601 |
| θ10 | 0.805 | 0.137 |
| θ11 | 3.95 | 1.04 |
|
| ||
| Interindividual variability (CV%) | ||
| ωCL/Φ = 31.8% | ||
| ωV1/F = 32.7% | ||
| ωQ = 47.5% | ||
| ωV2/F = 119.6% | ||
| ωKa = 56.8% | ||
| Residual variability | ||
| Proportional (%) 27.9 | ||
| Additive (ng ml−1) 0.425 | ||