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. 2005 Jan;59(1):43–53. doi: 10.1111/j.1365-2125.2005.2250.x

Table 5.

Summary of bootstrap validation on the present population pharmacokinetic model

Final estimates of the model parameters Results of 200 bootstrap simulations Mean SE Bootstrap mean/final estimate ratio (%)>
CL/F  19.1  18.1   7.48  95.0
V1/F 174 203 102.9 116.7
Q  34.4  34.8   3.94 101.2
V2/F 452 515 199 114.0
Ka   1.18   1.21   0.114 102.6
CL/F: FOOD   1.41   1.43   0.100 101.2
V1/F: FOOD   1.75   1.76   0.165 100.5
Absorption lag time: FOOD   0.234   0.232   0.039  99.2
CL/F: FORM   1.06   1.07   0.063 100.9
CL/F: WT   0.805   0.811   0.149 100.8
V1/F: WT   3.95   3.56   1.63  90.2
ω2CL/Φ   0.101   0.104   0.028 103.4
ω2V1/Φ   0.107   0.105   0.034  97.9
ω2Q   0.226   0.217   0.134  95.9
ω2V2/Φ   1.43   1.42   0.476  99.3
ω2Ka   0.323   0.363   0.093 112.3
σ2 (proportional)   0.0776   0.0755   0.010  97.3
σ2 (additive)   0.181   0.164   0.125  90.6