Table 2.

Haemodynamic effects of intravenous GTN infusion starting 40 min after the oral administration of NMI 861 or placebo to healthy subjects

Mean change from baseline* ± SEM (P value) and mean difference between treatments with 95% Cl GTN infusion (µg min−1)†
	Mean baseline* ± SEM (P value) and mean difference with 95% Cl	2.5	5	10	20	40	Mean maximum change from baseline* ± SEM (P value) and mean difference with 95% CI
Systolic blood pressure (mmHg)
Placebo	119.0 ± 2.1	−4.5 ± 1.6	−2.4 ± 1.4	−1.9 ± 1.3	−1.4 ± 1.9	−2.4 ± 2.1	−13.6 ± 2.4
NMI 861	123.4 ± 2.8	−2.9 ± 2.3	−2.8 ± 2.7	−1.7 ± 3.1	−5.7 ± 3.3	−7.4 ± 3.0	−16.9 ± 3.4
	(P = 0.106)	(P = 0.528)	(P = 0.893)	(P = 0.971)	(P = 0.329)	(P = 0.198)	(P = 0.460)
	4.4 (−1.1, 9.9)	1.6 (−3.8, 7.0)	−0.4 (−6.6, 5.8)	0.2 (−8.1, 8.3)	−4.3 (−13.6, 5.0)	−5.0 (−13.0, 3.0)	−3.3 (−12.7, 6.1)
Diastolic blood pressure (mmHg)
Placebo	68.5 ± 2.2	−2.1 ± 1.1	−0.4 ± 1.3	−1.2 ± 1.0	−0.9 ± 1.4	−7.7 ± 2.5	−14.0 ± 2.0
NMI 861	70.1 ± 2.3	−0.4 ± 1.4	0.8 ± 1.2	−1.1 ± 1.7	−4.9 ± 1.9	−8.2 ± 2.1	−14.7 ± 2.0
	(P = 0.478)	(P = 0.418)	(P = 0.384)	(P = 0.963)	(P = 0.144)	(P = 0.898)	(P = 0.835)
	1.6 (−3.3, 6.5)	1.8 (−1.2, 2.4)	1.1 (−1.7, 3.9)	0.1 (−5.1, 5.2)	−4.0 (−9.7, 1.7)	−0.5 (−8.9, 7.9)	−0.7 (−8.2, 6.8)
Pulse rate (beats min−1)
Placebo	61.6 ± 2.2	0.6 ± 0.9	−0.5 ± 1.2	0.0 ± 1.7	1.0 ± 1.4	5.1 ± 2.3	14.1 ± 2.4
NMI 861	65.8 ± 2.5	1.3 ± 1.2	1.4 ± 1.5	−0.7 ± 1.4	−0.9 ± 1.4	2.5 ± 1.3	11.8 ± 1.9
	(P = 0.134)	(P = 0.718)	(P = 0.396)	(P = 0.792)	(P = 0.458)	(P = 0.373)	(P = 0.464)
4.1 (−1.5, 9.7)	0.7 (−3.4, 4.8)	1.9 (−2.9, 6.7)	−0.7 (−6.1, 4.7)	−1.9 (−7.4, 3.6)	−2.6 (−8.7, 3.5)	−2.4 (−9.3, 4.5)

n = 12 subjects.

^†Each dose of GTN was infused for 15 min before the dose was doubled.

^*P values were determined by paired t-test.