Table 2.

Summary of the univariate analysis for levocetirizine

Effect	ΔOBJF	Symbol	Parameter estimate	s.e.	Ranka
Age on CL/F	−31.227	θCL	0.548	0.0541	3
CL/F = θCL + θCL,AGE × AGE		θCL, AGE	0.0104	0.00205
Age on V/F	−10.352	θV	2.23	3.34	5
V/F = θV + θV,AGE × AGE		θV, AGE	0.228	0.140
Weight on CL/F	−56.200	θCL	0.0991	0.110	1
CL/F = θCL + θCL,WT × WT		θCL, WT	0.0546	0.00864
Weight on V/F	−22.698	θV	3 × 10−13	0.0781
V/F = θV + ΘV,WT × WT		θV, WT	0.575	0.0598
Weight on V/F- Linear model (θV = 0)	−22.698	θV, WT	0.575	0.0615	4
BSA on CL/F	−57.048	θCL,BSA	1.43	0.0389
CL/F = θCL,BSA × BSA		θCL, miss	1.16	0.0832
BSA on V/F	−17.054	θV,BSA	13.5	1.44
V/F = θV,BSA × BSA		θV, miss	16.7	9.48
CLcr on CL/F	−39.616	θCL	0.478	0.0978	2
CL/F = θCL + θCL,CLcr × CLcr		θCL, CLcr	0.0126	0.00329
		θCL, miss	0.405	0.128
Gender on CL/F	−1.203	θCL,M	0.859	0.0292
CL/F = θCL,M (1-SEX) + θCL,F × SEX		−θCL,Φ	0.818	0.0325
Gender on V/F	−4.330	θV,M	9.70	1.34
V/F = θV,M (1-SEX) + θV,F × SEX		θV,Φ	7.62	0.806
Allergen sensitization on CL/F	−4.832	θCL,NO	0.821	0.0238
CL/F = θCL,NO × (1 − ALLG) + θCL,ALLG × ALLG		θCL,ALLG	0.923	0.0521
Hydroxyzine on CL/F	−0.002	θCL,NO	0.841	0.0235
CL/F = θCL,NO × (1-ATAR) + θCL, ATAR × ATAR		θCL,ATAR	0.845	0.106
Penicillins on CL/F	−0.082	θCL,NO	0.840	0.0241
CL/F = θCL,NO × (1-PENC) + θCL, PENC × PENC		θCL,PENC	0.860	0.0820
Corticosteroids on CL/F	−2.965	θCL,NO	0.843	0.0235
CL/F = θCL,NO × (1-CORT) + θCL, CORT × CORT		θCL,CORT	0.611	0.0896
Macrolides on CL/F	−2.279	θCL,NO	0.843	0.0239
CL/F = θCL,NO × (1-MACR) + θCL, MACR × MACR		θCL,MACR	0.657	0.1210
Diarrhoea/gastroenteritis on CL/F	−0.762	θCL,NO	0.844	0.0204
CL/F = θCL,NO × (1-DIAR) + θCL, DIAR × DIAR		θCL,DIAR	0.793	0.0562
Eosinophily on CL/F	−1.145	θCL, NO	0.835	0.0258
CL/F = θCL,NO × (1-EOS) + θCL,EOS × EOS		θCL, EOS	0.865	0.0344
		θCL, miss	0.0124	0.0708

^aRanking according to the decrease in objective function (P < 0.005) as compared with the basic model.