Table 3.
Estimated doses (90% confidence intervals) required by Pari LC Plus and Evohaler to generate an equivalent response to 100 µg. 5 g salbutamol via for Aerodose® Inhaler for efficacy and systemic endpoints. Estimated dose required by Evohaler to generate an equivalent response to 100 µg. 5 g salbutamol via Pari LC Plus is also shown
| Measure | Dose via Pari equivalent to 100 µg via Aerodose® Inhaler | Dose via Evohaler equivalent to 100 µg via Aerodose® Inhaler | Dose via Evohaler equivalent to 100µg via Pari |
|---|---|---|---|
| FEV1 (L) | 495 (526–714) | 495 (526–714) | 100 (93–107) |
| FEF25–75 (L/ s) | 366 (323–417) | 366 (323–417) | 100 (99–101) |
| K+ (mmol/l) | 278 (256–303) | 100 (93–109) | 36 (33–39) |
| Heart Rate (bpm) | 1235 (1000–1667) | 270 (222–345) | 22 (17–26) |
| QTc Interval (ms) | 559 (500–625) | 270 (244–303) | 48 (43–53) |
| T wave Amplitude (mV) | 735 (667–833) | 100 (90–111) | 14 (12–15) |