Table 3.

NAC in cardiology

Disease	Dose of NAC	Results
High plasma lipoprotein(a) concentration	(1) Orally 2 g day⁻¹ 4 weeks→ 4 g day⁻¹ 4 weeks	(1) Concentration reduction of 70% [83]
	(2) Orally 4 g day⁻¹ 2 weeks	(2) No effect on lipoprotein(a), reduction of homocysteine levels [82]
Unstable angina pectoris, conventional therapy	(1) i.v.i. 5 g 6 hourly + i.v.i. NG	(1) Fewer infarcts, but severe hypotension [82]
	(2) Orally 600 mg three times daily + transdermal NG, 4 months	(2) Fewer cardiac events, but intolerable headache [82]
Acute myocardial infarction	i.v.i. 15 g per 24 h	Decreased level of oxidative stress, more rapid reperfusion, better left ventricular preservation [82]
Acute myocardial infarction	i.v.i. 100 mg kg⁻¹	Reduced infarct size, better preservation of global and regional left ventricular function, rudimentary R wave or R wave recovery in left precordial leads [82]
Angina pectoris, normal left ventricular function	i.v.i. bolus 2 g, then 5 mg kg⁻¹ h⁻¹	NAC attenuated tolerance development to continuous NG infusion [12]
Chronic heart failure	(1) Orally 200 mg kg ⁻¹+ i.v.i. NG	(1) NG tolerance partly disappeared [82]
	(2) i.v.i. 100 mg kg⁻¹ per 30 min + ISDNi	(2) Haemodynamic effects of ISDNi potentiated [82]
Viral myocarditis, case report	i.v.i. 150 mg kg⁻¹ per 15 min, 6.25 mg kg⁻¹ h⁻¹	Positive inotropic effect [82]
Cardiac catheterization in patients with or without atherosclerosis	i.a. 48 mg min⁻¹	Coronary and peripheral endothelium-dependent vasodilation improved [82]

NG, Nitroglycerine; ISDNi, isosorbidedinitrate.