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. 2006 Jan;61(1):5–15. doi: 10.1111/j.1365-2125.2005.02523.x

Table 4.

NAC in cardiac surgery

Operation with CPB Dose of NAC Results
Elective CABG i.v.i. 100 mg kg−1 1 h before, 40 mg kg−1 day−1 after CPB Improvement of systemic oxygenation [84]
Cardiac surgery Combination of antioxidants including NAC Protection of pulmonary endothelial function [85]
Coronary artery surgery 100 mg kg−1 into cardiopulmonary bypass prime, then infusion at 20 mg kg−1 h−1 Attenuation of myocardial oxidative stress [27]
Cardiac surgery As above Myocardial apoptosis signal cascade induced by cardioplegic arrest effectively prevented [27]
CABG i.v.i. 50 mg kg−1 3 days Decrease of pump-induced oxidoinflammatory response during CPB [86]

CPB, Cardiopulmonary bypass; CABG, coronary artery bypass grafting.