Table 2.

Amikacin population pharmacokinetic parameter estimates

Parameter	Estimate	PPV	%SE
CLstd (l h−1 per 70 kg) at 24  weeks PCA, without NSAID	0.486	0.336	7.2
Vstd (l per 70 kg)	40.2	0.451	3.3
SLPCL (l week−1)	0.11	–	12.5
FNSAID	0.788	–	4.5
Residual unidentified variability  (mg l−1)	1.59	31.7

PPV is the population parameter variability expressed as the square root of its variance, SE is the standard error of the estimate. V = [Vstd ×(Wt/70)] l per 70 kg; CL =[CLstd ×^{(Wt/70) 0.}75] ×EXP[SLPCL ×(PCA-24) ×FNSAID] l h⁻¹ per 70 kg where Vstd and CLstd are the population estimates for V and CL, respectively, standardized to a 70-kg person using allometric models; PCA is the post-conception age in weeks; SLPCL is the factor relating PCA to developmental changes in CL; FNSAID is a scaling factor for those premature neonates given a NSAID. Err is the residual additive error.