Table 4.

Weight- and age-related amikacin parameters and dosing recommendations predicted using the allometric ‘1/4 Power’ Model (per 70 kg)

Age, weeks PCA	Weight, kg	CL, l h−1 per 70 kg	CL, l h−1	V, l per 70 kg	V, l	Maintenance dose, mg	Dosing interval, h
24	0.5	0.486	0.012	40.2	0.29	6.0	44
25	0.6	0.543	0.015	40.2	0.34	7.2	41
26	0.8	0.606	0.021	40.2	0.46	9.6	40
27	0.9	0.676	0.026	40.2	0.52	10.9	37
28	1	0.755	0.031	40.2	0.57	12.1	34
29	1.15	0.842	0.039	40.2	0.66	13.9	31
30	1.3	0.94	0.047	40.2	0.75	15.7	29