Table 5.
Concentrations during the two study periods and for the simulation study. Target concentration intervention (TCI) resulted in improved concentration profiles
Concentration | 1999–2002 n = 129 | 2002–2004 n = 76 | Total study period n = 205 | Predictive check n = 1000 | TCI n = 1000 |
---|---|---|---|---|---|
<5 mg l–1 | 27.9% | 61.8% | 40.5% | 36% | 87% |
>20 mg l–1 | 94.5% | 93% | 94.2% | 94% | 77% |
Average concentration1 | 18.8 mg l–1 | 12.9 mg l–1 | 16.5 mg l–1 | 16.6 mg l–1 | 8.8 mg l–1 |
Estimated from geometric mean of measured (or simulated) peak and trough concentrations.