Table 1.

Summary of ruboxistaurin and N-desmethyl ruboxistaurin pharmacokinetic parameters before and after induction with rifampicin

	Ruboxistaurin			N-desmethyl ruboxistaurin
Parameter	Without rifampicin	With rifampicin	Ratio† of geometric means (90% CI)	Without rifampicin	With rifampicin	Ratio† of geometric means (90% CI)
n	17	16	–	17	16	–
Cmax	200	10.7	0.049	128	42.1	0.316
(nmol l−1)b	(63.3)	(5.68)	(0.041, 0.059)*	(37.6)	(16.4)	(0.271, 0.368)*
AUC(0,tlast)	1216	53.4	0.041	1640	373	0.222
(nmol l−1 h)b	(420)	(28.0)	(0.034, 0.050)*	(551)	(121)	(0.193, 0.256)*
AUC(0,∞)	1364	60.4	0.042	1831	406	0.219
(nmol l−1 h)b	(429)	(28.0)	(0.035–0.051)*	(600)	(122)	(0.189, 0.253)*
t1/2b	13.8	2.28	0.186	20.6	13.7	0.658
(h)	(10.1)	(0.82)	(0.141, 0.244)*	(7.09)	(3.87)	(0.562, 0.769)*
tmaxa	2.00	2.00	0.417c	2.50	2.00	0.374c
(h)	(1.00–4.00)	(0.500, 6.00)		(1.50, 4.00)	(0.500, 6.00)
CL/Fb	109	2639	23.5	NC	NC	NC
(l h−1)	(29.8)	(996)	(20.0, 28.5)*
VZ/Fb	2107	8718	4.35	NC	NC	NC
(l)	(1819)	(4548)	(3.23, 5.88)*

^at_max data are given as the median values with ranges

^bvalues are shown as the arithmetic mean (+ SD.)

^cP values based on Wilcoxon Signed Rank test

^†ratio of geometric means after: before rifampicin induction; P value ≤ 0.001; CI = confidence interval; NC = not calculated.