. 2005 Dec 20;61(2):127–137. doi: 10.1111/j.1365-2125.2005.02544.x

Table 2.

Haemodynamic and biological parameters obtained during tilt and exercise tests

Parameters	Treatment	Tilt1	Exercise 1	Tilt2	Exercise 2
Heart rate (bpm)	Placebo	74 ± 4	153 ± 7	77 ± 4^‡	156 ± 7^§
	Ivabradine	59 ± 2^*^†	121 ± 4^*	60 ± 3^*^†^‡	124 ± 5^*^§
	Propranolol	65 ± 2^*	121 ± 3^*	69 ± 3^*^‡	129 ± 5^*^§
Systolic blood pressure (mmHg)	Placebo	123 ± 3	146 ± 2	125 ± 3	141 ± 7
	Ivabradine	126 ± 5^†	143 ± 4	121 ± 4^†	151 ± 4
	Propranolol	112 ± 4^*	144 ± 2	114 ± 3^*	148 ± 3
Diastolic blood pressure (mmHg)	Placebo	71 ± 3	106 ± 5	68 ± 2	109 ± 9
	Ivabradine	71 ± 4	110 ± 5	70 ± 3	94 ± 6
	Propranolol	64 ± 3	107 ± 3	65 ± 2	102 ± 6
Mean blood pressure (mmHg)	Placebo	88 ± 3	120 ± 4	87 ± 2	120 ± 9
	Ivabradine	89 ± 4^†	121 ± 5	87 ± 3^†	113 ± 4
	Propranolol	80 ± 3^*	119 ± 3	81 ± 2^*	117 ± 4
Rate pressure product (10³ mmHg min⁻¹)	Placebo	9.12 ± 0.63	22.43 ± 1.14	9.62 ± 0.64^‡	22.33 ± 1.85^§
	Ivabradine	7.33 ± 0.37^*	17.30 ± 0.83^*	7.26 ± 0.55^*^‡	18.71 ± 0.78^*^§
	Propranolol	7.26 ± 0.38^*	17.43 ± 0.51^*	7.96 ± 0.44^*^‡	19.04 ± 0.84^*^§
Cardiac index (l m⁻¹ m⁻²)	Placebo	3.7 ± 0.2	11.0 ± 0.7	4.7 ± 0.3^‡	12.2 ± 0.9^§
	Ivabradine	3.7 ± 0.3^†	10.8 ± 0.7	4.7 ± 0.5^†^‡	13.0 ± 1.2^§
	Propranolol	3.2 ± 0.2^*	10.0 ± 1.0	4.1 ± 0.4^*^‡	12.1 ± 1.0^§
Total peripheral resistance index (dynes s cm⁻⁵)	Placebo	2021 ± 116	898 ± 71	1522 ± 91^‡	845 ± 106^§
	Ivabradine	2021 ± 188	944 ± 79	1579 ± 131^‡	738 ± 62^§
	Propranolol	2011 ± 146	1042 ± 119	1687 ± 127^‡	824 ± 86^§
Epinephrine (pg ml⁻¹)	Placebo	41 ± 8	80 ± 13	30 ± 0^‡	57 ± 10^§
	Ivabradine	33 ± 3	103 ± 13	30 ± 0^‡	59 ± 8^§
	Propranolol	51 ± 9	149 ± 28^*^†	31 ± 1^‡	90 ± 13^§^*^†
Norepinephrine (pg ml⁻¹)	Placebo	325 ± 24	985 ± 99	352 ± 41	997 ± 123
	Ivabradine	358 ± 27	1133 ± 146	348 ± 31	989 ± 133
	Propranolol	333 ± 24	1223 ± 154	338 ± 27	1021 ± 111

Values are mean ± SEM. Parameters are obtained at 5 min, during the first (Tilt1) and the second tilt test (Tilt 2) and at 10 min during the first (Exercise 1) and second exercise test (Exercise 2). The two sets of tests were performed, respectively, 2 and 5 h after treatment administration.

P < 0.05 vs. placebo

^†

P < 0.05 Ivabradine vs. Propranolol at each measurement time

^‡

P < 0.05 vs. Tilt 1

^§

P < 0.05 vs. Exercise 1.