Table 5.
Estimates (95% confidence intervals) of the intercept and gradients from the regression analysis of the influence from pentoxifylline (Ptx) and its metabolites (R-M1, S-M1, M4, and M5) on retinal blood flow measured as mean flow, systole, diastole and pulsation after administration of placebo and pentoxifylline 300 mg intravenous infusion alone and in combination with ciprofloxacin 750-mg tablet and pretreatment with rifampicin 600-mg tablets once daily for 7 days, on four separate occasions
| Mean flow | Systole | Diastole | Pulsation* 1000 | |
|---|---|---|---|---|
| Intercept | 245 | 327 | 167 | 490 |
| AU† | (186, 304) | (256, 398) | (122, 211) | (440, 540) |
| AUC Ptx | 17.1* | 36.4* | 3.47 | 33.9 |
| AU†/(µg−1 h−1 ml) | (4.31, 29.9) | (17.6, 55.3) | (−10.6, 17.6) | (−0.37, 68.1) |
| AUC R-M1 | 303* | 168 | 301* | −367 |
| AU†/(µg−1 h−1 ml) | (147, 459) | (−62.6, 399) | (128, 474) | (−804, 71.0) |
| AUC S-M1 | −9.58* | −12.1* | −4.66* | −7.51 |
| AU†/(µg−1 h−1 ml) | (−13.6, 5.52) | (−18.1, 6.05) | (−9.15, 0.158) | (−18.7, 3.7) |
| AUC M4 | −54.5* | −96.1* | −280 | −49.7 |
| AU†/(µg−1 h−1 ml) | (−93.4, 15.5) | (−154, 38.4) | (−71.2, 15.2) | (−159, 59.3) |
| AUC M5 | 6.66* | 9.62* | 3.52 | 4.04 |
| AU†/(µg−1 h−1 ml) | (0.675, 12.6) | (0.762, 18.5) | (−3.12, 10.2) | (−12.7, 20.8) |
*
P < 0.05.
†
Except for pulsation.