Table 3.

Serum hormone concentrations following administration of the combined oral contraceptive (COC) alone or with lamotrigine (300 mg)

(a) FSH, LH, oestradiol and SHBG
	Day 5 to day 7 (COC alone) (n = 22)		Day 89 to day 91 (COC + lamotrigine 300 mg) (n = 16)
Hormone	Geometric mean	Range	Geometric mean	Range
FSH (IU l−1)a	1.02	<0.50–5.20	4.80	0.94–12.5
LH (MIU l−1)a	0.70	<0.50–3.20	2.40	<0.5–8.90
Oestradiol (pmol l−1)b	<73.0c	<73.0c	86.8	<73.0–279
SHBG (nmol l−1)	158	50.0–375	115	57.0–242

(b) Progesterone
	Day 20 to day 22 (COC alone) (n = 22)		Day 104 to day 106 (COC + lamotrigine 300 mg) (n = 16)
Hormone	Geometric mean	Range	Geometric mean	Range
Progesterone (nmol l−1)a	1.47	<1.00–2.90	1.28	<1.00–2.20

^aFor the purposes of summary statistics, values < 0.50 IU l⁻¹were set at 0.50 IU l⁻¹

^bFor the purposes of summary statistics, values < 73.0 pmol l⁻¹were set at 73.0 pmol l⁻¹

^cAll values < 73.0 pmol l⁻¹FSH, follicle stimulating hormone; LH, luteinizing hormone; SHBG, sex hormone binding globulin. Normal ranges: FSH (IU l⁻¹) = 3.0–10.2; LH (IU l⁻¹) = Follicular: 1.8–13.4, Mid-cycle: 15.6–79, Luteal: 0.7–19.4; Oestradiol (pmol l⁻¹) = Follicular: 37–184, Mid-cycle: 41–1377, Luteal: 55–422; SHBG (nmol l⁻¹) = 18–114.

^aFor the purposes of summary statistics, values < 1.00 nmol l⁻¹were set at 1.00 nmol l⁻¹. Normal ranges: Progesterone (nmol l⁻¹) = Follicular: 0.5–4.5, Luteal: 5.1–67, Mid-luteal: 17.0–73.0.