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Observed dapsone (DDS) concentrations and simulated DDS concentrations (using population mean parameter estimates in Table 3) vs. time for the Zambian adults (○) and Gambian children (•). [Dosing of 200 mg for the Zambian adults and 56.25 and 28.1 mg for the Gambian children of chlorproguanil (as part of Lapdap) daily for 3 days. Note, other doses were administered to the Gambian children, for clarification only two doses were presented on the graph.]
