Table 3.
Population pharmacokinetic parameters of chlorproguanil (CPG) and dapsone (DDS) for the base model
| Parameter | Estimate (SE) | Interpatient variability (% CV) |
|---|---|---|
| CPG | ||
| ka (h−1) | 0.09 (0.01) | 44 |
| CL/F (l h−1) | 51.53 (3.81) | 57 |
| CLD/F (l h−1) | 54.67 (5.77) | |
| V1/F (l) | 234.40 (31.82) | 50 |
| V2/F (l) | 1612.75 (149.50) | |
| σɛ* (% CV) | 39 | |
| AUC (ng ml−1 h−1) = | 3105 | |
| dose/CL/F | (for an adult dose of 160 mg) | |
| t1/2 elim (h) | 34.7 | |
| DDS | ||
| ka (h−1) | 0.93 (0.05) | |
| CL/F (l h−1) | 1.99 (0.16) | 72 |
| V/F (l) | 76.96 (3.95) | 48 |
| σɛ* (% CV) | 33 | |
| AUC (ng ml−1 h−1) = | 100503 | |
| dose/CL/F | (for an adult dose of 200 mg) | |
| t1/2 elim (h) | 26.67 | |
*
Lognormal error model.