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Trough plasma perhexiline concentration (mg l−1) (A) and plasma cis-OH-perhexiline to perhexiline metabolic ratio (B) in patients with either one or two functional CYP2D6 alleles following a standard perhexiline loading regime of 200 mg twice per day for 3 days. Patients without a CYP2D6*2 allele are represented with open symbols and those possessing at least one CYP2D6*2 allele are represented with closed symbols
