Table 1.
Geometric mean (SD) pharmacokinetic parameters and statistical comparisons (ratios[90% CI]) after administration of lamotrigine with olanzapine (LTZ + OLZ), lamotrigine with placebo (LTG) or olanzapine with placebo (OLZ)
| Lamotrigine pharmacokinetic parameters | |||
|---|---|---|---|
| LTG + OLZ [N = 16] | LTG [N = 12] | Ratio LTG + OLZ:LTG [90% CIs] | |
| Cmax (ug ml−1) | 4.29 (1.04) | 5.36 (0.43) | 0.80 [0.71, 0.90] |
| AUC(0−24) (ug h ml−1) | 66.2 (24.2) | 87.2 (11.5) | 0.76 [0.65, 0.90)] |
| Median (range) Tmax (h) | 2.00 (0.50–4.00) | 2.00 (1.00–4.00) | NA |
| Olanzapine pharmacokinetic parameters | |||
| LTG + OLZ [N = 16] | OLZ [N = 16] | Ratio LTG + OLZ:OLZ [90% CIs] | |
| Cmax (ng ml−1) | 45.9 (10.7) | 44.4 (11.6) | 1.03 [0.90, 1.19] |
| AUC(0−24) (ng h ml−1) | 817 (174) | 786 (223) | 1.04 [0.90, 1.20] |
| Median (range) Tmax (h) | 3.06 (2.00–8.02) | 4.00 (1.50–8.00) | NA |