Table 1.
Drugs/age | Body weight (kg) | Obs CL (l h−1) | Pred CL (0.75) | Pred CL (0.8) | Pred CL (0.85) | Pred CL (1.0) | Pred CL L + K | Pred CL (mixed) |
---|---|---|---|---|---|---|---|---|
Morphine | ||||||||
<1 week | 3.5 | 1.365 | 6.513 | 5.607 | 4.827 | 3.080 | 3.560 | 3.080 |
1 week to 2 months | 3.9 | 2.106 | 7.064 | 6.114 | 5.292 | 3.432 | 3.903 | 3.432 |
2–6 months | 6.2 | 7.936 | 10.001 | 8.860 | 7.848 | 5.456 | 6.657 | 5.456 |
0.5–2.5 years | 7.2 | 9.360 | 11.188 | 9.985 | 8.912 | 6.336 | 7.559 | 7.559 |
Adult | 70 | 61.600 | ||||||
Fentanyl | ||||||||
<1month | 3.2 | 3.104 | 5.536 | 4.745 | 4.067 | 2.560 | 2.999 | 2.560 |
1–12 months | 5.9 | 6.431 | 8.760 | 7.741 | 6.840 | 4.720 | 5.802 | 4.720 |
1–5 years | 17.3 | 11.937 | 19.629 | 18.304 | 17.068 | 13.840 | 16.650 | 16.650 |
Adult | 70 | 56.000 | ||||||
Remifentanil | ||||||||
2–12 years | 18 | 63.360 | 62.435 | 58.336 | 54.506 | 44.460 | 53.171 | 62.435 |
Adult | 70 | 172.900 | ||||||
Bupivacine | ||||||||
1–21 days | 3.2 | 0.704 | 3.183 | 2.728 | 2.338 | 1.472 | 1.725 | 1.472 |
5.5–10 years | 23 | 13.800 | 13.974 | 13.218 | 12.502 | 10.580 | 12.197 | 13.974 |
Adult | 70 | 32.200 | ||||||
Ketamine | ||||||||
<3 months | 4 | 3.200 | 9.817 | 8.508 | 7.374 | 4.800 | 5.438 | 4.800 |
3–12 months | 8 | 16.800 | 16.511 | 14.814 | 13.291 | 9.600 | 11.274 | 9.600 |
4 years | 15 | 22.500 | 26.456 | 24.495 | 22.679 | 18.000 | 22.123 | 22.123 |
Adult | 70 | 84.000 | ||||||
Midazolam | ||||||||
1–7 days (premature) | 2 | 0.149 | 1.925 | 1.611 | 1.349 | 0.791 | 0.995 | 0.791 |
1–7 days term | 3 | 0.300 | 2.609 | 2.229 | 1.904 | 1.187 | 1.404 | 1.187 |
34–41 weeks (gestational) | 3.1 | 1.264 | 2.674 | 2.288 | 1.958 | 1.227 | 1.444 | 1.227 |
Mean 5.2 years | 17.3 | 9.460 | 9.709 | 9.054 | 8.443 | 6.846 | 8.236 | 9.709 |
Adult | 70 | 27.700 | ||||||
Atenolol | ||||||||
5–16 years | 20 | 3.310 | 3.283 | 3.083 | 2.896 | 2.400 | 2.825 | 3.283 |
Adult | 70 | 8.400 | ||||||
Salbutamol | ||||||||
54–105 days | 2.2 | 1.000 | 2.374 | 1.997 | 1.679 | 0.999 | 1.239 | 1.000 |
Adult | 70 | 31.800 |