Table 1.

Predicted and observed clearance (l h⁻¹) in children using different methods

Drugs/age	Body weight (kg)	Obs CL (l h−1)	Pred CL (0.75)	Pred CL (0.8)	Pred CL (0.85)	Pred CL (1.0)	Pred CL L + K	Pred CL (mixed)
Morphine
<1 week	3.5	1.365	6.513	5.607	4.827	3.080	3.560	3.080
1 week to 2 months	3.9	2.106	7.064	6.114	5.292	3.432	3.903	3.432
2–6 months	6.2	7.936	10.001	8.860	7.848	5.456	6.657	5.456
0.5–2.5 years	7.2	9.360	11.188	9.985	8.912	6.336	7.559	7.559
Adult	70	61.600
Fentanyl
<1month	3.2	3.104	5.536	4.745	4.067	2.560	2.999	2.560
1–12 months	5.9	6.431	8.760	7.741	6.840	4.720	5.802	4.720
1–5 years	17.3	11.937	19.629	18.304	17.068	13.840	16.650	16.650
Adult	70	56.000
Remifentanil
2–12 years	18	63.360	62.435	58.336	54.506	44.460	53.171	62.435
Adult	70	172.900
Bupivacine
1–21 days	3.2	0.704	3.183	2.728	2.338	1.472	1.725	1.472
5.5–10 years	23	13.800	13.974	13.218	12.502	10.580	12.197	13.974
Adult	70	32.200
Ketamine
<3 months	4	3.200	9.817	8.508	7.374	4.800	5.438	4.800
3–12 months	8	16.800	16.511	14.814	13.291	9.600	11.274	9.600
4 years	15	22.500	26.456	24.495	22.679	18.000	22.123	22.123
Adult	70	84.000
Midazolam
1–7 days (premature)	2	0.149	1.925	1.611	1.349	0.791	0.995	0.791
1–7 days term	3	0.300	2.609	2.229	1.904	1.187	1.404	1.187
34–41 weeks (gestational)	3.1	1.264	2.674	2.288	1.958	1.227	1.444	1.227
Mean 5.2 years	17.3	9.460	9.709	9.054	8.443	6.846	8.236	9.709
Adult	70	27.700
Atenolol
5–16 years	20	3.310	3.283	3.083	2.896	2.400	2.825	3.283
Adult	70	8.400
Salbutamol
54–105 days	2.2	1.000	2.374	1.997	1.679	0.999	1.239	1.000
Adult	70	31.800