Table 1b.

Predicted and observed clearance (l h⁻¹) in children using different methods

Drugs/age	Body weight (kg)	Obs CL (l h−1)	Pred CL (0.75)	Pred CL (0.8)	Pred CL (0.85)	Pred CL (1.0)	Pred CL L + K	Pred CL (mixed)
Lamotrigine
<6 years	15	0.740	0.728	0.674	0.624	0.495	0.608	0.728
>6 years (3.8–11.3 years)	35	1.160	1.374	1.327	1.282	1.155	1.250	1.374
Adult	70	2.310
Amprenavir
4–12 years	26.67	31.740	23.520	22.412	21.356	18.479	20.835	23.520
Adult	70	48.500
Gatifloxacin
0.5–2 years	10	3.100	2.993	2.715	2.464	1.840	2.090	2.090
2–6 years	17	6.290	4.456	4.151	3.868	3.128	3.773	4.456
6–12 years	30	9.040	6.822	6.539	6.268	5.520	6.115	6.822
12–16 years	48	11.170	9.706	9.524	9.346	8.832	9.119	9.706
Adult	70	12.880
Caffeine
1–7 days (premature)	2	0.013	0.409	0.342	0.286	0.168	0.211	0.168
7–28 days (premature)	3	0.036	0.554	0.473	0.404	0.252	0.298	0.252
1–3 months	5	0.250	0.812	0.712	0.624	0.420	0.460	0.420
3–12 months	8	0.820	1.156	1.037	0.930	0.672	0.789	0.672
Adult	70	5.880
Vancomycin
7–28 days (premature)	3	0.200	0.527	0.450	0.384	0.240	0.283	0.240
1–7 days (term)	3	0.150	0.527	0.450	0.384	0.240	0.283	0.240
7–28 days (term)	4	0.230	0.653	0.566	0.491	0.319	0.362	0.319
1–3 months	5	0.600	0.772	0.677	0.593	0.399	0.438	0.399
3–12 months	8	0.800	1.099	0.986	0.885	0.639	0.750	0.639
Adult	70	5.590
Cefetamet
IV 3–5 years	15.8	2.830	2.574	2.389	2.218	1.774	2.164	2.164
5.5–12 years	30.8	4.360	4.246	4.076	3.912	3.458	3.816	4.246
Adult	70	7.860
Chloramphenicol
Premature	2	0.210	1.049	0.878	0.735	0.431	0.542	0.431
Infant	5	0.760	2.086	1.828	1.602	1.079	1.182	1.182
Child	20	1.900	5.901	5.543	5.206	4.314	5.079	5.079
Adult	70	15.100
Valproic acid
0–2 months	5	0.072	0.140	0.122	0.107	0.072	0.079	0.072
2–36 months	10	0.190	0.235	0.213	0.193	0.144	0.162	0.235
3–9 years	22	0.310	0.424	0.400	0.378	0.317	0.368	0.424
10–18 years	50	0.930	0.785	0.772	0.759	0.721	0.740	0.785
Adult	70	1.010