Table 1b.
Drugs/age | Body weight (kg) | Obs CL (l h−1) | Pred CL (0.75) | Pred CL (0.8) | Pred CL (0.85) | Pred CL (1.0) | Pred CL L + K | Pred CL (mixed) |
---|---|---|---|---|---|---|---|---|
Lamotrigine | ||||||||
<6 years | 15 | 0.740 | 0.728 | 0.674 | 0.624 | 0.495 | 0.608 | 0.728 |
>6 years (3.8–11.3 years) | 35 | 1.160 | 1.374 | 1.327 | 1.282 | 1.155 | 1.250 | 1.374 |
Adult | 70 | 2.310 | ||||||
Amprenavir | ||||||||
4–12 years | 26.67 | 31.740 | 23.520 | 22.412 | 21.356 | 18.479 | 20.835 | 23.520 |
Adult | 70 | 48.500 | ||||||
Gatifloxacin | ||||||||
0.5–2 years | 10 | 3.100 | 2.993 | 2.715 | 2.464 | 1.840 | 2.090 | 2.090 |
2–6 years | 17 | 6.290 | 4.456 | 4.151 | 3.868 | 3.128 | 3.773 | 4.456 |
6–12 years | 30 | 9.040 | 6.822 | 6.539 | 6.268 | 5.520 | 6.115 | 6.822 |
12–16 years | 48 | 11.170 | 9.706 | 9.524 | 9.346 | 8.832 | 9.119 | 9.706 |
Adult | 70 | 12.880 | ||||||
Caffeine | ||||||||
1–7 days (premature) | 2 | 0.013 | 0.409 | 0.342 | 0.286 | 0.168 | 0.211 | 0.168 |
7–28 days (premature) | 3 | 0.036 | 0.554 | 0.473 | 0.404 | 0.252 | 0.298 | 0.252 |
1–3 months | 5 | 0.250 | 0.812 | 0.712 | 0.624 | 0.420 | 0.460 | 0.420 |
3–12 months | 8 | 0.820 | 1.156 | 1.037 | 0.930 | 0.672 | 0.789 | 0.672 |
Adult | 70 | 5.880 | ||||||
Vancomycin | ||||||||
7–28 days (premature) | 3 | 0.200 | 0.527 | 0.450 | 0.384 | 0.240 | 0.283 | 0.240 |
1–7 days (term) | 3 | 0.150 | 0.527 | 0.450 | 0.384 | 0.240 | 0.283 | 0.240 |
7–28 days (term) | 4 | 0.230 | 0.653 | 0.566 | 0.491 | 0.319 | 0.362 | 0.319 |
1–3 months | 5 | 0.600 | 0.772 | 0.677 | 0.593 | 0.399 | 0.438 | 0.399 |
3–12 months | 8 | 0.800 | 1.099 | 0.986 | 0.885 | 0.639 | 0.750 | 0.639 |
Adult | 70 | 5.590 | ||||||
Cefetamet | ||||||||
IV 3–5 years | 15.8 | 2.830 | 2.574 | 2.389 | 2.218 | 1.774 | 2.164 | 2.164 |
5.5–12 years | 30.8 | 4.360 | 4.246 | 4.076 | 3.912 | 3.458 | 3.816 | 4.246 |
Adult | 70 | 7.860 | ||||||
Chloramphenicol | ||||||||
Premature | 2 | 0.210 | 1.049 | 0.878 | 0.735 | 0.431 | 0.542 | 0.431 |
Infant | 5 | 0.760 | 2.086 | 1.828 | 1.602 | 1.079 | 1.182 | 1.182 |
Child | 20 | 1.900 | 5.901 | 5.543 | 5.206 | 4.314 | 5.079 | 5.079 |
Adult | 70 | 15.100 | ||||||
Valproic acid | ||||||||
0–2 months | 5 | 0.072 | 0.140 | 0.122 | 0.107 | 0.072 | 0.079 | 0.072 |
2–36 months | 10 | 0.190 | 0.235 | 0.213 | 0.193 | 0.144 | 0.162 | 0.235 |
3–9 years | 22 | 0.310 | 0.424 | 0.400 | 0.378 | 0.317 | 0.368 | 0.424 |
10–18 years | 50 | 0.930 | 0.785 | 0.772 | 0.759 | 0.721 | 0.740 | 0.785 |
Adult | 70 | 1.010 |