Table 1d.

Predicted and observed clearance (l h⁻¹) in children using different methods

Drugs/age	Body weight (kg)	Obs CL (l h−1)	Pred CL (0.75)	Pred CL (0.8)	Pred CL (0.85)	Pred CL (1.0)	Pred CL L + K	Pred CL (mixed)
Ciprofloxacin, urinary tract
<1 year	7.7	7.580	9.667	8.657	7.752	5.567	6.575	5.567
1year	11	12.080	12.632	11.515	10.498	7.953	10.240	10.240
2–5 years	15.9	16.500	16.652	15.462	14.358	11.496	14.006	14.006
≥6 years	22.5	32.940	21.605	20.413	19.287	16.268	18.815	21.605
Adult	70	50.610
Cisapride
Mean postnatal age 31 days	1.74	0.790	1.780	1.480	1.230	0.707	0.908	0.707
41 days	2.96	2.230	2.652	2.264	1.933	1.203	1.426	1.703
77 days	4.52	3.820	3.643	3.177	2.770	1.836	2.043	2.482
Adult	70	28.440
Oxycodone
2.3–4.7 years	15.9	14.480	15.398	14.298	13.277	10.630	13.000	13.000
6.1–9.8 years	25.2	22.870	21.751	20.667	19.638	16.848	19.230	21.751
Adult	70	46.800
Irbesartan
1–5 years	20.2	5.580	4.567	4.292	4.033	3.347	3.949	3.949
6–12 years	53.5	12.000	9.482	9.355	9.231	8.866	9.041	9.482
13–17 years	80.3	14.400	12.858	12.946	13.036	13.307	12.769	12.858
Adult	70	11.600
Darbepoetin alfa
I.v. 1–16 years	35.3	0.081	0.066	0.064	0.061	0.055	0.060	0.066
Adult	70	0.112
S.c. 1–16 years	35.3	0.150	0.180	0.173	0.168	0.151	0.164	0.180
Adult	70	0.300
Celecoxib
<10 years	25.5	28.050	16.412	15.603	14.835	12.750	14.527	16.412
>10 years	49	34.300	26.785	26.312	25.846	24.500	25.314	26.785
Adult	70	35.000
Trovafloxacin
0.6 years	6	0.890	1.076	0.951	0.841	0.582	0.716	0.582
1.75–4 years	15	2.710	2.139	1.980	1.833	1.455	1.795	1.795
8.5–12.5 years	30	3.390	3.597	3.447	3.304	2.910	3.236	3.597
Adult	70	6.790
Ketoprofen
0.6–7.75 years	22	1.540	2.116	1.997	1.884	1.584	1.845	1.845
Adult	70	5.040