Table 1d.
Drugs/age | Body weight (kg) | Obs CL (l h−1) | Pred CL (0.75) | Pred CL (0.8) | Pred CL (0.85) | Pred CL (1.0) | Pred CL L + K | Pred CL (mixed) |
---|---|---|---|---|---|---|---|---|
Ciprofloxacin, urinary tract | ||||||||
<1 year | 7.7 | 7.580 | 9.667 | 8.657 | 7.752 | 5.567 | 6.575 | 5.567 |
1year | 11 | 12.080 | 12.632 | 11.515 | 10.498 | 7.953 | 10.240 | 10.240 |
2–5 years | 15.9 | 16.500 | 16.652 | 15.462 | 14.358 | 11.496 | 14.006 | 14.006 |
≥6 years | 22.5 | 32.940 | 21.605 | 20.413 | 19.287 | 16.268 | 18.815 | 21.605 |
Adult | 70 | 50.610 | ||||||
Cisapride | ||||||||
Mean postnatal age 31 days | 1.74 | 0.790 | 1.780 | 1.480 | 1.230 | 0.707 | 0.908 | 0.707 |
41 days | 2.96 | 2.230 | 2.652 | 2.264 | 1.933 | 1.203 | 1.426 | 1.703 |
77 days | 4.52 | 3.820 | 3.643 | 3.177 | 2.770 | 1.836 | 2.043 | 2.482 |
Adult | 70 | 28.440 | ||||||
Oxycodone | ||||||||
2.3–4.7 years | 15.9 | 14.480 | 15.398 | 14.298 | 13.277 | 10.630 | 13.000 | 13.000 |
6.1–9.8 years | 25.2 | 22.870 | 21.751 | 20.667 | 19.638 | 16.848 | 19.230 | 21.751 |
Adult | 70 | 46.800 | ||||||
Irbesartan | ||||||||
1–5 years | 20.2 | 5.580 | 4.567 | 4.292 | 4.033 | 3.347 | 3.949 | 3.949 |
6–12 years | 53.5 | 12.000 | 9.482 | 9.355 | 9.231 | 8.866 | 9.041 | 9.482 |
13–17 years | 80.3 | 14.400 | 12.858 | 12.946 | 13.036 | 13.307 | 12.769 | 12.858 |
Adult | 70 | 11.600 | ||||||
Darbepoetin alfa | ||||||||
I.v. 1–16 years | 35.3 | 0.081 | 0.066 | 0.064 | 0.061 | 0.055 | 0.060 | 0.066 |
Adult | 70 | 0.112 | ||||||
S.c. 1–16 years | 35.3 | 0.150 | 0.180 | 0.173 | 0.168 | 0.151 | 0.164 | 0.180 |
Adult | 70 | 0.300 | ||||||
Celecoxib | ||||||||
<10 years | 25.5 | 28.050 | 16.412 | 15.603 | 14.835 | 12.750 | 14.527 | 16.412 |
>10 years | 49 | 34.300 | 26.785 | 26.312 | 25.846 | 24.500 | 25.314 | 26.785 |
Adult | 70 | 35.000 | ||||||
Trovafloxacin | ||||||||
0.6 years | 6 | 0.890 | 1.076 | 0.951 | 0.841 | 0.582 | 0.716 | 0.582 |
1.75–4 years | 15 | 2.710 | 2.139 | 1.980 | 1.833 | 1.455 | 1.795 | 1.795 |
8.5–12.5 years | 30 | 3.390 | 3.597 | 3.447 | 3.304 | 2.910 | 3.236 | 3.597 |
Adult | 70 | 6.790 | ||||||
Ketoprofen | ||||||||
0.6–7.75 years | 22 | 1.540 | 2.116 | 1.997 | 1.884 | 1.584 | 1.845 | 1.845 |
Adult | 70 | 5.040 |