Table 2a.

Percent error in predicted and observed clearance in children using different methods

Drugs/age	Pred CL (0.75)	Pred CL (0.80)	Pred CL (0.85)	Pred CL (1.0)	Pred CL L + K	Pred CL (mixed)
Theophylline
1–7 days (premature)	−443	−354	−280	−123	−180	−123
7–28 days (premature)	−179	−139	−104	−27	−50	−27
1–7 days	−395	−326	−267	−133	−170	−133
7–28 days	−271	−223	−182	−87	−107	−87
1–3 months	−122	−95	−71	−15	−26	−15
2–5 years	19	25	30	45	32	32
6.5–12 years	17	22	26	37	28	17
Antipyrine
<12 years	14	20	25	39	27	14
>12 years	1	5	9	20	12	1
Lorazepam
<1 year	−860	−719	−600	−336	−417	−336
2–12 years	−13	−5	2	20	4	4
>12–18 years	−23	−17	−13	1	−10	−23
Famotidine
0–3 months	−335	−277	−227	−113	−141	−113
>3–12 months	−67	−48	−32	8	−12	8
1.1–12.9 years	−39	−30	−22	−1	−19	−19
Levofloxacin
I.v. 0.5 to <2 years	29	36	42	57	51	51
2 to <5 years	30	35	40	53	42	42
5 to <10 years	22	26	30	40	32	22
10 to <12 years	12	14	16	21	18	12
12–16 years	12	13	14	17	16	12
Lamotrigine
<6 years	2	9	16	33	18	2
>6 years (3.8–11.3 years)	−18	−14	−11	0	−8	−18
Amprenavir
4–12 years	26	29	33	42	34	26
Gatifloxacin
0.5–2 years	3	12	21	41	33	33
2–6 years	29	34	39	50	40	29
6–12 years	25	28	31	39	32	25
12–16 years	13	15	16	21	18	13