Table 2b.

Percent error in predicted and observed clearance in children using different methods

Drugs/age	Pred CL (0.75)	Pred CL (0.80)	Pred CL (0.85)	Pred CL (1.0)	Pred CL L + K	Pred CL (mixed)
Caffeine
1–7 days (premature)	−3046	−2531	−2100	−1192	−1523	−1192
7–28 days (premature)	−1439	−1214	−1022	−600	−728	−600
1–3 months	−225	−185	−150	−68	−84	−68
3–12 months	−41	−26	−13	18	4	18
Vancomycin
7–28 days (premature)	−164	−125	−92	−20	−42	−20
1–7 days (term)	−251	−200	−156	−60	−89	−60
7–28 days (term)	−184	−146	−113	−39	−57	−39
1–3 months	−29	−13	1	34	27	34
3–12 months	−37	−23	−11	20	6	20
Cefetamet
I.v. 3–5 years	9	16	22	37	24	24
5.5–12 years	3	7	10	21	12	3
Chloramphenicol
Premature	−400	−318	−250	−105	−158	−105
Infant	−174	−141	−111	−42	−56	−56
Child	−211	−192	−174	−127	−167	−167
Valproic acid
0–2 months	−94	−69	−49	0	−10	0
2–36 months	−24	−12	−2	24	15	−24
3–9 years	−37	−29	−22	−2	−19	−37
10–18 years	16	17	18	22	20	16
Erythromycin estolate
1.5 days	−62	−39	−19	26	13	26
15 days	−90	−64	−41	10	−4	10
0.29 days	−72	−49	−29	16	5	16
19 months	−211	−184	−159	−96	−153	−153
Tiagabine
Valproate 6 years	39	42	45	54	47	39
Induced 6 years	−7	−1	4	18	6	−7
Omeprazole
0.25–1 year	−99	−77	−58	−12	−34	−12
0.3–1.6 years	−111	−91	−74	−30	−47	−47
4–15 years	−116	−107	−99	−75	−94	−116