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Goodness-of-fit plots from the final population pharmacokinetic model (all data are log-transformed). (A) Observed vs. predicted MTX concentrations. (B) Observed vs. individual Bayesian predicted MTX concentrations. (C) Observed vs. the model predicted 7-OH-MTX concentrations. (D) Observed vs. individual Bayesian predicted of 7-OH-MTX concentrations.
