Table 2. Summary of subject characteristics at baseline.
| Subject characteristics | Index data set1 | Test data set2 | Combined data set | Missing covariates3 |
|---|---|---|---|---|
| Age (years) | 56.0 (22.0–81.0) | 62.0 (18.0–89.0) | 60.0 (18.0–89.0) | 0.0 |
| Body weight (kg) | 71.8 (44.0–124) | 69.8 (34.0–145) | 70.0 (34.0–145) | 1.3 |
| Body surface area (m2) | 1.85 (1.38–2.57) | 1.80 (1.18–2.68) | 1.81 (1.18–2.68) | 3.5 |
| Sex (number) | 0.0 | |||
| Male | 93 | 487 | 603 | |
| Female | 73 | 394 | 480 | |
| Race (number) | 0.0 | |||
| Caucasian | 156 | 858 | 1014 | |
| African-American | 6 | 14 | 20 | |
| Others | 4 | 45 | 49 | |
| Subject status (number) | 0.0 | |||
| Healthy | 12 | 36 | 48 | |
| Cancer | 154 | 881 | 1035 | |
| ALT (IU l–1) | 25.5 (3.0–142) | 26.0 (4.0–400) | 25.5 (3.0–400) | 2.1 |
| AST (IU l–1) | 25.0 (6.0–125) | 26.0 (4.0–249) | 26.0 (4.0–249) | 2.5 |
| Alkaline phosphatase (IU l–1) | 103 (40–1030) | 148 (23–3180) | 133 (23–3180) | 1.2 |
| Lactate dehydrogenase (IU l–1) | 384 (141–3320) | 370 (22–7900) | 387 (22–7900) | 8.8 |
| Total bilirubin (µmol l–1) | 9.0 (3.0–41.0) | 10.0 (2.0–116) | 10.0 (2.0–116) | 1.8 |
| Serum albumin (g l–1) | 41.0 (25.0–57.0) | 38.0 (13.0–60.0) | 38.0 (13.0–60.0) | 19.7 |
| Total protein (g l–1) | 70.5 (48.0–86.0) | 70.0 (24.0–102) | 70.0 (24.0–102) | 7.8 |
| Creatinine clearance4 (ml min–1) | 98.0 (33.0–150) | 88.0 (20.0–150) | 90.5 (20.0–150) | 2.1 |
Continuous variables are expressed as median (range), whereas categorical variables are expressed as counts.
1
Range of observations: 1.0–4932 ng ml−1
2
Range of observations: 2.3–6266 ng ml−1
3
Missing covariates expressed as percentage of subjects in the combined data set with missing values.
4
Creatinine clearance was calculated using Cockroft-Gault formula and values higher than 150 ml min−1 were truncated to 150 ml min−1