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. 2006 May 2;62(1):81–96. doi: 10.1111/j.1365-2125.2006.02615.x

Table 3. Summary of covariate analysis: backward elimination.

Model Covariate effect ΔMVOF Degrees of freedom P value
10 Healthy status on CL −17.410 1 –
11 Healthy status on V2 −23.415 1 <0.00001
12 Healthy status on Q4 −57.431 1 <0.00001
13 Healthy status on V4 −50.314 1 <0.00001
14 Healthy status on D1 −11.745 1 0.00061
15 Healthy status on KA −14.901 1 0.00011
16 Liquid formulation on ALAG1 −82.642 1 <0.00001
17 Liquid formulation on D1 −42.831 1 <0.00001
18 Liquid formulation on KA −36.299 1 <0.00001
19 WGT on V22 −30.176 1 <0.00001
20 TBIL on CL −9.894 1 0.00166

1Apart from the disease status and the formulation effect, the full model included the following covariate effects: AST and TBIL on CL, WGT and SEX on V2, WGT on F1 and CLCR on ALAG1

2

The power coefficient quantifying the effect of WGT on V2 was not statistically different from 1 (Δ MVOF = –1.748, d.f. = 1, P = 0.186). Δ MVOF Change in the minimum value of the objective function.