Table 2.
Pharmacokinetic parameter estimates for the two-compartment model
| Parameters | Base model | SE% | Parameters | Final model | SE% |
|---|---|---|---|---|---|
| CL (l h−1) | 0.693 | 9.5 | CLmissing (l h−1) | 0.972 | 10.5 |
| θNR | N/A | N/A | θNR (l h−1) | 0.229 | N/A |
| θCrCL | N/A | N/A | θCrCL (1/4.8 CrCL) | 0.744 | 18.7 |
| V2 (l) | 7.07 | 22.5 | V2 (l per 70 kg weight) | 6.78 | 19.2 |
| V3 (l) | 5.99 | 25.4 | V3 (l) | 6.19 | 24.9 |
| Q (l h−1) | 0.494 | 27.9 | Q (lh−1) | 0.429 | 24.7 |
| Ka (h−1) | 0.428 | 29.0 | Ka (h−1) | 0.476 | 27.3 |
| F1 | 1 | 1.1 | F1 | 0.94 | 9.7 |
| ωcl% | 65.5 | 44.1 | ωcl% | 40.7 | 23.8 |
| ωv2% | 61.9 | 31.3 | ωv2% | 29.4 | 82.2 |
| σ1% | 22.6 | 28.4 | σ1% | 12.1 | 100 |
| σ2 (IU l−1) | 75.4 | 36.6 | σ2 (IU l−1) | 132 | 44.7 |
| σ3% | 43.1 | 26.0 | σ3% | 44.0 | 26.3 |
CL, Clearance; CrCL, creatinine clearance; IU, international units; SE, standard error; weight, total body weight; V2, volume of distribution of central compartment; V3, volume of distribution of peripheral compartment; ω, coefficient of variation of interindividual variability; σ1, proportional coefficient of variation of residual error for general medical unit patients; σ2, additive coefficient of variation of residual error for general medical unit patients; σ3, proportional coefficient of variation of residual error for ICU patients; N/A, not available; θNR, 0.229 (fixed); unit of weight = kg, unit of CrCL = l h−1; F1, absolute bioavailability.